Frequent co-expression of the HOXA9 and MEIS1 homeobox genes in human myeloid leukemias
نویسندگان
چکیده
منابع مشابه
C/EBPα is an essential collaborator in Hoxa9/Meis1-mediated leukemogenesis.
Homeobox A9 (HOXA9) is a homeodomain-containing transcription factor that plays a key role in hematopoietic stem cell expansion and is commonly deregulated in human acute leukemias. A variety of upstream genetic alterations in acute myeloid leukemia (AML) lead to overexpression of HOXA9, almost always in association with overexpression of its cofactor meis homeobox 1 (MEIS1) . A wide range of d...
متن کاملMeis1 programs transcription of FLT3 and cancer stem cell character, using a mechanism that requires interaction with Pbx and a novel function of the Meis1 C-terminus.
Meis1 is a homeodomain transcription factor coexpressed with Hoxa9 in most human acute myeloid leukemias (AMLs). In mouse models of leukemia produced by Hoxa9, Meis1 accelerates leukemogenesis. Because Hoxa9 immortalizes myeloid progenitors in the absence of Meis1 expression, the contribution of Meis1 toward leukemia remains unclear. Here, we describe a cultured progenitor model in which Meis1 ...
متن کاملHOXA9 is required for survival in human MLL-rearranged acute leukemias.
Leukemias that harbor translocations involving the mixed lineage leukemia gene (MLL) possess unique biologic characteristics and often have an unfavorable prognosis. Gene expression analyses demonstrate a distinct profile for MLL-rearranged leukemias with consistent high-level expression of select Homeobox genes, including HOXA9. Here, we investigated the effects of HOXA9 suppression in MLL-rea...
متن کاملMYELOID NEOPLASIA C-terminal domain of MEIS1 converts PKNOX1 (PREP1) into a HOXA9- collaborating oncoprotein
The three-amino-acid loop extension (TALE) class homeodomain proteins MEIS1 and PKNOX1 (PREP1) share the ability to interact with PBX and HOX family members and bind similar DNA sequences but appear to play opposing roles in tumor development. Elevated levels of MEIS1 accelerate development of HOXand MLL-induced leukemias, and this pro-tumorigenic property has been associated with transcription...
متن کاملMight as well face it: MLL's addicted to HOX.
Chromosomal rearrangements involving the MLL gene are a characteristic feature of a variety of human leukemias, including acute lymphoid (ALL) and acute myeloid leukemias (AML) as well as secondary leukemias resulting from treatment with topoisomerase inhibitors.1 The MEIS1 and HOXA9 genes have been shown to be major downstream targets of MLL fusion proteins.2 The mammalian HOX genes encode DNA...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Leukemia
سال: 1999
ISSN: 0887-6924,1476-5551
DOI: 10.1038/sj.leu.2401578